Synthesis, characterization and identification of inhibitory activity on the main protease of COVID-19 by molecular docking strategy of (4-oxo-piperidinium ethylene acetal) trioxonitrate.

In this investigation a single crystal of (4-oxo-piperidinium ethylene acetal) trioxonitrate (4-OPEAN) was synthesized by modifying the mechanism of gradual evaporation at ambient temperature. The operational groupings are found in the complex material in the elaborate substance, according to the infrared spectrum. Single crystal X-ray diffraction suggests, (4-OPEAN) with the chemical formula (C7H12NO2)NO3 belongs to the orthorhombic space group Pnma and is centrosymmetric in three dimensions with the aforementioned network configurations, a = 11.7185(8) Å, b = 7.2729(6) Å, c = 11.0163(8) Å, Z = 4, V = 938.89(12) Å3, R = 0.0725 and wR = 0.1762. Many N-H…O and C-H…O hydrogen bridges, both bifurcated and non-bifurcated, link the 4-oxo-piperidinium ethylene acetal cations to the trigonal (NO3-) anions. Molecular geometry and optimal parameters of (4-OPEAN) have been determined via DFT computations at the theory-level B3LYP/6-311 ++ G(d, p), these have been contrasted with the X-ray data already available. Hirshfeld surface analysis has made it possible for the visualization and quantification of relationships between molecules in the crystal composition. Quantum theory atoms in molecules, electron location function, decreased density gradient, and localized orbital locator research have all been used to explore non-covalent interactions in crystal structure. In order to pinpoint both the nucleophilic and electrophilic locations that support hydrogen bond formation, the molecule electrostatic potential was determined. The greatest and lowest energies of occupied and unfilled molecular orbitals, together with additional derived atomic characteristics, show the material to be extremely stable and hard. According to a molecular docking study, 4-OPEAN may exhibit inhibiting effects on the 6Y84 and 7EJY virus proteins from corona (COVID-19).

Islamic Social Funds to Foster Yunusian Social Business and Conventional Social Enterprises

This paper proposes an integrated, comprehensive financial model that can provide startup capital to socially committed business ventures, such as social enterprises and Yunus Social Business (YSB), by using Islamic social funds (ISFs), Zakat (almsgiving), Waqf (endowments), Sadaqat (charity), and Qard Hasan (interest-free benevolent loans). The literature review method was adopted to explain this model's architecture, applications, implications, and viability. On the basis of logical reasoning, it concludes that ISFs can yield greater social wellbeing if utilised in SEs and YSB than in unconditional charity because both business models work for social betterment in entrepreneurial ways while remaining operationally self-reliant and economically sustainable. Additionally, ISFs can complement Yunus Social Business's zero-return investment approach to make it more robust towards social contributions. The implementation of the model orchestrated in this paper would enhance societal business practices and, hence, scale up social wellbeing while helping rejuvenate pandemic-stricken economies. It paves the way for new research too. © 2023 by the authors.

THE EFFECT OF CORPORATE FRUGALITY ON CRISIS PREPAREDNESS: THE MEDIATING ROLE OF ENTREPRENEURIAL ORIENTATION

This study explores relationships between Corporate Frugality (CF), Entrepreneurial Orientation (EO) and Crisis Preparedness (CP). CP was proposed as the surrogate measure for firm performance during actual crises. EO is also examined as a potential mediator in the CF-CP association. The hypotheses were tested using partial least squares structural equation modeling with data collected from randomly selected small businesses operating in the Tripolitania region of northwestern Libya during the current economic instability caused by civil unrest. Further, COVID-19 pandemic cases had significantly risen among the population at the time of the study. The findings show that CF can be instrumental in responding to market crisis requirements, while innovativeness only results in better CP and partially mediates the CF-CP association. These findings validate the CF construct, but entrepreneurs must cautiously proceed when exercising EO in response to crises. Furthermore, the study casts new light on how the association between EO dimensions and performance can differ across contexts. Building on the resource-based view and pecking order theory and integrating them with contingency theory, this study is the first to explore the effect of EO and its dimensions as the mediator between CF and CP. © 2023 World Scientific Publishing Company.

Opportunities in Disruption: Higher Education in the Post COVID-19 Era

Due to its ravaging impacts, the World Health Organization (WHO) declared COVID-19 as a global pandemic on 11 March 2020. Higher education institutions were not spared, as the pandemic and associated lockdown measures disrupted traditional knowledge transmission, leading to the quick adoption of online learning to protect students and ensure the continuity of education. The disruption proved challenging to higher education institutions, forcing instructors and students to quickly adapt to online education and its challenges during lockdown and isolation. However, and despite the challenges of online education, early evidence suggests that hybrid and blended modes of education will become the post-COVID-19 new normal for higher education. This chapter provides insight into some critical impacts and inherent opportunities in the disruption caused by COVID-19 in the higher education sector. Higher education institutions can capitalize on digitalization to enhance the students' access to education, provide flexibility, and transform higher education in a technologically advanced, competitive, and unpredictable global environment. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Decision Tree and Random Forest Models for Internal Audit Effectiveness Factors Evaluation

this paper investigates the impact of auditors' competency, independency, member's size, and digital transformation as factors that enhance the effectiveness of internal audit in Bahraini Context during and after Covid-19 outbreak. In this quantitative study, this paper used a survey questionnaire. The survey used to collect data for a sample of 50 respondents from both public and private organization in Bahrain to measure the study variables among auditors. Findings, there is a strong relationship between internal audit effectiveness and management support, digital transformation, and IA member's size. While independency, competency, and auditors' experience positively affect the internal audit effectiveness. The results of this paper will encourage decision makers of such organizations to focus on the issue of that enhance the effectiveness of internal audit after pandemic outbreaks and will strengthen the internal audit capacity of these organizations. This Paper offer academic contributions to existing research of internal audit effectiveness in developing context. The decision trees and Random Forest approaches used in this paper will allow future researchers to reclassify the factors that enhance the effectiveness of internal audit. © 2023 IEEE.

Heparin-based versus bivalirudin-based anticoagulation in pediatric extracorporeal membrane oxygenation: A systematic review.

Introduction: Optimal anticoagulation therapy is essential for the prevention of thrombotic and hemorrhagic complications in pediatric patients supported with extracorporeal membrane oxygenation (ECMO). Recent data have demonstrated bivalirudin has the potential to surpass and replace heparin as the anticoagulant of choice. Methods: We conducted a systematic review comparing the outcomes of heparin-based versus bivalirudin-based anticoagulation in pediatric patients supported on ECMO to identify the preferred anticoagulant to minimize bleeding events, thrombotic complications, and associated mortality. We referenced the PubMed, Cochrane Library, and Embase databases. These databases were searched from inception through October 2022. Our initial search identified 422 studies. All records were screened by two independent reviewers using the Covidence software for adherence to our inclusion criteria, and seven retrospective cohort studies were identified as appropriate for inclusion. Results: In total, 196 pediatric patients were anticoagulated with heparin and 117 were anticoagulated with bivalirudin while on ECMO. Across the included studies, it was found that for patients treated with bivalirudin, trends were noted toward lower rates of bleeding, transfusion requirements, and thrombosis with no difference in mortality. Overall costs associated with bivalirudin therapy were lower. Time to therapeutic anticoagulation varied between studies though institutions had different anticoagulation targets. Conclusion: Bivalirudin may be a safe, cost-effective alternative to heparin in achieving anticoagulation in pediatric ECMO patients. Prospective multicenter studies and randomized control trials with standard anticoagulation targets are needed to accurately compare outcomes associated with heparin versus bivalirudin in pediatric ECMO patients.

Testosterone and Covid-19: An update.

There is overwhelming evidence to suggest that male gender is at a higher risk of developing more severe Covid-19 disease and thus having poorer clinical outcomes. However, the relationship between testosterone (T) and Covid-19 remains unclear with both protective and deleterious effects on different aspects of the disease suggested. Here, we review the current epidemiological and biological evidence on the role of testosterone in the process of SARS-CoV-2 infection and in mediating Covid-19 severity, its potential to serve as a biomarker for risk stratification and discuss the possibility of T supplementation as a treatment or preventative therapy for Covid-19.

Evaluation of Clinical Predictors for Major Outcomes in Patients Hospitalized With COVID-19: The Potential Role of the Rothman Index.

Introduction The Rothman Index (RI, PeraHealth, Inc. Charlotte, NC, USA) is a predictive model intended to provide continuous monitoring of a patient's clinical status. There is limited data to support its use in the risk stratification of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We hypothesized that low admission RI scores would correlate with higher rates of adverse outcomes in patients hospitalized for coronavirus disease 2019 (COVID-19). Methods Medical records of adult patients admitted to a single 1,200-bed tertiary academic center were retrospectively reviewed for demographic data, baseline characteristics, RI scores, admission to intensive care unit (ICU), need for mechanical ventilation, and inpatient mortality. Statistical analyses were performed using STATA statistical software, version 17 (Stata Corp LLC, College Station, TX, USA). Continuous variables were analyzed using the Mann-Whitney test, and categorical variables were analyzed using Fisher's exact test. Both univariate and multivariate analyses were performed. A p-value <0.05 was considered statistically significant. Results Median admission RI score for the entire cohort was 63.0 (IQR 45.0 - 77.1). The cohort was divided by admission RI into a low-risk group (RI ≥70; n=70) and a high-risk group (RI <70; n=107). Compared to patients with low-risk RI, patients with high-risk RI had higher mortality (95.2%, 95% CI: 85.8 - 105 vs 4.8%, 95% CI: -5 - 14.2, p < 0.01), were more likely to require ICU admission (90.2%, 95% CI: 81.9 - 98.5 vs 9.8%, 95% CI: 1.5 - 18.1, p < 0.01) and mechanical ventilation (89.7%, 95% CI: 78.3 - 101 vs 10.3%, 95% CI: -1 - 21.7, p < 0.01), and had a longer median hospital length of stay (12 days, 95% CI: 9 - 14 vs 5 days, 95% CI: 4 - 7, p < 0.01). Conclusions High-risk RI was associated with increased admission to the ICU, mechanical ventilation, and mortality. These results suggest that it may be used as a tool to aid provider judgment in the setting of COVID-19.

Consensus recommendations for COVID-19-related myocarditis in athletes: proof of concept-case report.

Background: Post-viral myocarditis has been associated with sudden cardiac death in athletes. Since the beginning of the COVID-19 pandemic, the concern of post-viral myocarditis impacting the professional athletic community has been present. Case summary: An elite-level basketball player presented after a positive COVID-19 test with findings consistent with ventricular tachycardia related to myocardial fibrosis/scar from a COVID-19-related myocarditis. Although rare, COVID-19 myocarditis can occur. This case illustrates how the consensus guidelines for return-to-play correctly identified the player as high risk with appropriate downstream evaluation by cardiac magnetic resonance (CMR) imaging. The stepwise approach is illustrated in this case and highlights the utility and success of the algorithm when approaching athletes with COVID-19-related myocarditis risk and determining a return to exercise. Discussion: Diligence is required to identify competitive athletes with features suggestive of myocarditis at the initial presentation and with the return to exercise. Cardiopulmonary symptoms in the setting of recent COVID-19 infection should prompt additional testing in a stepwise fashion and often benefit from CMR in addition to the triad testing with electrocardiography, echocardiography, and cardiac troponin measurement to further investigate clinical presentations of COVID-19-related myocarditis.

Metal complexes of Tridentate Schiff base: Synthesis, Characterization, Biological Activity and Molecular Docking Studies with COVID-19 Protein Receptor.

Mononuclear chelates of Cr(III), Mn(II), Fe(III), Ni(II), Cu(II), Zn(II) and Cd(II) resulted from new tridentate Schiff base ligand, 4-((1-(5-acetyl-2,4-dihydroxyphenyl)ethylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, were synthesized. Metal to ligand ratio was found to be1 : 1, which was revealed via elemental analysis and characterized via various spectroscopic tools. IR has point out that the coordination of the ligand towards the metal ions was carried out via NOO donor atoms. UV-Vis, 1H NMR spectral data, molar conductivity measurements, BET surface area, melting points and theoretically through density function theory were used such as characterizing techniques in supporting further interpretation of the complexes structures. The complexes were octahedral except Cu(II) and Ni(II) complexes were tetrahedral as suggested from the magnetic moment measurement. The complexes were found to have surface area, pore volume and particle radius of 23-176 m2 g-1, 0.02-0.33 cc/g and 8.71-4.32 nm, respectively, as pointed out from BET measurement. Schiff base ligand and metal complexes were tested in vitro to estimate their antimicrobial activity opposed to Gram-negative and Gram-positive bacterial and fungal organisms. MOE 2008 was used headed for screen potential drugs with molecular docking by the protein sites of new coronavirus and the study was constructed to molecular docking without validation through MD simulations.

Highlights on molecular targets in the management of COVID-19: Possible role of pharmacogenomics.

By the end of 2022, there had been a reduction in new cases and deaths caused by coronavirus disease 2019 (COVID-19). At the same time, new variants of the severe acute respiratory syndrome coronavirus 2 virus were being discovered. Critically ill patients with COVID-19 have been found to have high serum levels of proinflammatory cytokines, especially interleukin (IL)-6. COVID-19-related mortality has been attributed in most cases to the cytokine storm caused by increased levels of inflammatory cytokines. Dexamethasone in low doses and immunomodulators such as IL-6 inhibitors are recommended to overcome the cytokine storm. This current narrative review highlights the place of other therapeutic choices such as proteasome inhibitors, protease inhibitors and nuclear factor kappa B inhibitors in the treatment of patients with COVID-19.

COVID-19 effect on patients with noncommunicable diseases: A narrative review.

Background and Aims: On March 11, 2020, the WHO has declared COVID-19 a global pandemic, affecting our day-to-day lives. Physical distancing and lockdown made significant obstacles to populations, particularly healthcare systems. Most healthcare workers were reallocated to COVID-19 facilities. Noncommunicable disease patients were given low priority and are at a higher risk of severe COVID-19 infection, which disrupted the treatment and disease management of these patients. This review aimed to assess the effect of COVID-19 on different types of noncommunicable diseases and the severity it may cause to patients. Methods: We have conducted a review of the literature on COVID-19 and noncommunicable diseases from December 2019 until January 2022. The search was done in PubMed and Cochrane for relevant articles using variety of searching terms. Data for study variables were extracted. At the end of the selection process, 46 papers were selected for inclusion in the literature review. Result: The result from this review found that the COVID-19 pandemic has affected the efficiency of the patient's treatment indirectly by either delaying or canceling sessions, which solidified the need to rely more on telemedicine, virtual visits, and in-home visits to improve patient education and minimize the risk of exposure to the patients. The major and most common types of noncommunicable diseases are known to be related to the severe outcomes of COVID-19 infection. It is strongly recommended to prioritize these patients for vaccinations against COVID-19 to provide them with the protection that will neutralize the risk imposed by their comorbidities. Conclusion: We recommend conducting more studies with larger population samples to further understand the role of noncommunicable diseases (NCDs) in this pandemic. However, this pandemic has also affected the efficiency of NCDs treatment indirectly by delaying or canceling sessions and others.

Outcomes of Surgical Tracheostomy on Mechanically Ventilated COVID-19 Patients Admitted to a Private Tertiary Hospital in Tanzania.

OBJECTIVES:  The coronavirus disease 2019 (COVID-19) pandemic has resulted in an increase in the number of patients necessitating prolonged mechanical ventilation. Data on patients with COVID-19 undergoing tracheostomy indicating timing and outcomes are very limited. Our study illustrates--- outcomes for surgical tracheotomies performed on COVID-19 patients in Tanzania. METHODS:  This was a retrospective observational study conducted at the Aga Khan Hospital in Dar es Salaam, Tanzania. RESULTS:  Nineteen patients with COVID-19 underwent surgical tracheotomy between 16th March and 31st December 2021. All surgical tracheostomies were performed in the operating theatre. The average duration of intubation prior to tracheotomy and tracheostomy to ventilator liberation was 16 days and 27 days respectively. Only five patients were successfully liberated from the ventilator, decannulated, and discharged successfully. CONCLUSIONS:  This is the first and largest study describing tracheotomy outcomes in COVID-19 patients in Tanzania. Our results revealed a high mortality rate. Multicenter studies in the private and public sectors are needed in Tanzania to determine optimal timing, identification of patients, and risk factors predictive of improved outcomes.

Dyslexia assistive technology recommendation system for use during COVID-19 pandemic

During this challenging time, thousands of children had to switch to remote learning when they are at home. As such, this has impacted the children learning process at school and involved parent's engagement to support their children's learning. Dyslexia Assistive Technology Recommendation system is being developed to assist the problem faced by the parent who does not familiar with assistive technology that can be used in assisting their child. As most of their learning is at school, the parent is not aware of the assistive technology that can be used to assist their child at home. This system is developed using a modified waterfall model methodology. The project aim is to help in recommending the suitable assistive technology that can be used by the parent to assist their child while learning at home. At the end, the paper highlights the flow of process and user interface of the system which shows the type of dyslexia the child had along with the suggestion of the suitable assistive technology. © 2022 Author(s).

Analysing the interplay between the right to health and pharmaceutical patent rights in the introduction of a COVID-19 vaccine into the Philippines

Purpose>The COVID-19 pandemic has devastated economies and public health systems across the globe, increasing the anticipation for the creation of an effective vaccine. With this comes the reinforcement of debates between the right to health and pharmaceutical patent rights. The purpose of this study is to illustrate how the Philippines could attempt to balance the right to health with pharmaceutical patent rights in the introduction of a potential COVID-19 vaccine into the country.Design/methodology/approach>This will be accomplished through an examination of the flexibilities allowed by international agreements and domestic patent laws.Findings>With the economic and health challenges brought about by the COVID-19 pandemic, the Philippine Government will have a strong justification to pursue parallel importation and compulsory licencing under the Agreement on Trade-Related Aspects of Intellectual Property Rights. This is exacerbated by the bold leadership of President Duterte, whose administration has so far shown a propensity to decide in favor of the right to health at the expense of other rights in dealing with the pandemic.Originality/value>While this paper focuses on the Philippines, it has a potential application in the least developed and developing countries which aim to gain access to a prospective COVID-19 vaccine. Moreover, while this study discusses the harmonization of laws on the right to health and patent laws as a solution to the COVID-19 pandemic and the lack of access to vaccines, it also calls for solutions that go beyond the application of the law.

Searching for potential antiviral activity of medicinal plants against SARS-CoV-2

Introduction: COVID-19 is an infectious disease caused by the SARS-CoV-2, which severely affects the morbidity of people living with non-communicable diseases. Therefore, the Herbal Medicine Research Centre, Institute for Medical Research has taken the initiative to search for plant extracts and phytoconstituents with potential anti-SARS-CoV-2 properties in vitro. Material(s) and Method(s): The antiviral activities of potential plant-derived candidates against SARS-CoV-2 infection in Vero-E6 cells were assessed. The two steps viral induced-cytopathic effect (CPE) screening approach was used. Firstly, the SARS-CoV-2 was exposed with single doses (10 mug/mL or muM) of plant extracts and compounds after which the extracts and compounds with >=20% viral inhibitory activities were evaluated for dose-response antiviral activities. The dose-response antiviral activity for each extract and compound was quantitatively analyzed via a dose response curve using the Graphpad Prism software. Result(s) and Conclusion(s): From more than 60 plant extracts and compounds screened against the SARS-CoV-2 infection in vitro, at single dose exposure, 8 plant extracts and compounds showed >20% inhibition. Dose response analysis identified three plant extracts and one compound with potent antiviral activity (EC50<=10 mug/mL or muM) and high selectivity (SI>=10) towards the SARS-CoV-2. One of the extracts with potent anti-SARS-CoV-2 activity was derived from the E. longifolia plant, a Malaysian medicinal plant. Further evaluation on the efficacy of this plant's extract and compounds in SARS-CoV-2 infected human lung cells and a COVID- 19 animal model is warranted.

An Analysis of Aesthetic Concerns Identified by Video Conferencing.

Background During and after the coronavirus disease 2019 (COVID-19) pandemic, there was a significant increase in the demand for aesthetic procedures nationwide. We believe that one of the factors contributing to this increase was the use of video conferencing apps. Therefore, the purpose of this study was to analyze the aesthetic concerns that were identified by video conferencing. Methodology In Saudi Arabia, an observational, cross-sectional study was conducted from February to April, 2022. An online survey was used to assess the aesthetic concerns raised by video conferencing. The survey addressed multiple aspects, including demographic data, information on video call utilization, the attentional focus of the participants during video calls, and new appearance concerns identified on video calls. Results The survey successfully captured 432 adult participants. More than 85% of participants disliked at least one character of their appearance during video conferencing. The skin color type (based on the Fitzpatrick scale), time spent on video calls, and visual focus during the virtual meeting were significantly correlated with self-perception of new disliked features. Conclusion Video conferencing showed a significant statistical correlation with identified disliked facial/body features in both genders. People with skin color type III were less likely to perceive a disliked feature through video conferencing applications. The likelihood of having a disliked feature was significantly higher among individuals who spent up to one hour per day using video calls. Additionally, those who mainly paid attention to their face or body during virtual meetings were more likely to have disliked features.

Using NFTs for Product Management, Digital Certification, Trading, and Delivery in the Healthcare Supply Chain

The COVID-19 pandemic caused disruption in the healthcare market, which resulted in shortages of essential healthcare products. The pandemic exacerbated the problems that already existed in the healthcare supply chain, such as poor data availability, transparency, and accessibility. Such problems necessitate the introduction of a solution that is capable of managing products, maintaining ownership, facilitating trading, and delivering products in a traceable, auditable, and trustworthy manner. In this article, we propose a nonfungible-token-based solution for the management of healthcare products, where the ownership of a product is maintained by using digital certification, the trade and delivery of healthcare products is facilitated by a smart contract, and disputes are settled by an arbitrator while keeping all related information on-chain for auditing purposes. We utilize the Interplanetary File System to store the metadata of healthcare products to avoid storing large-sized data on the blockchain. We present system diagrams and algorithms along with the implementation details. We conduct security testing to demonstrate that our solution is resilient and secure against common vulnerabilities and exploits. We compare our solution with the existing solutions to show its distinctive features and novelty. The smart contracts code is made publicly available on GitHub. Author

Individual, Organizational, and Environmental Factors Affecting Work-Life Balance among Malaysian Lecturers Amidst Covid-19 Pandemic

Education plays a significant role in every country in this world. Nowadays, lecturers are burdened with many roles such as researcher, administrator, counsellor, and many others. The position of a lecturer is very important for the success of institutions. To provide a professional service, they should be mentally and physically fit. High levels of work stress were associated with lower work-life balance and increased conflicts in their jobs. The Covid-19 pandemic has made it tough for teachers duties of teaching online while working from home. So, it is important to see what factors matter to the lecturers in Malaysia in balancing their work and life. Therefore, this study seeks to identify the factors affecting work-life balance among lecturers in Malaysia. The dependent variable in this study was work-life balance while the independent variables were made up of three major factors;i.e., individual, organizational, and environmental with six sub-factors, namely emotional intelligence, spiritual intelligence, work overload, organizational support, technological advancement, and telecommuting. For this research, a total of 435 lecturers participated and were contacted by email for answering the online survey questionnaire, and the Statistical Package for Social Sciences Software (SPSS) was used to conduct multiple regression analysis in evaluating the relationships between the variables. The findings of this study revealed that the individual factors, organizational factors, and environmental factors were partially supported because only one sub-factor was significant in each factor. Work overload is the most influencing factor affecting the lecturer's work-life balance in Malaysia, while emotional intelligence is the least influencing factor. In addition, the result depicts that only emotional intelligence, work overload, and technological advancement made a significant impact on work-life balance. Whereas spiritual intelligence, organizational support, and significantly explain the variance in work-life balance significantly. The findings of the study provide the Ministry of Higher Education and policymakers with key information to increase and maintain the lecturers’ work-life balance. At the same time, this study improves their skills in managing their emotions and their time to meet their deadlines which can help foster and reinforce a separation between work and home environment. © 2022, Association Res Militaris. All rights reserved.

Innovation product development to curb the spread of Covid-19 by public universities in the east coast of Malaysia

The Covid-19 pandemic that hit the country in early 2020 has changed the lifestyles of people around the world. Day after day, the impact of this pandemic seems to be endless but the number of daily cases in Malaysia is increasing and the situation is very worrying for the country. Based on this scenario, facing this pandemic is an urgency while addressing it is a necessity that all Malaysians, including public university (PU) citizens, should face. The main objective of this paper is to identify the need for product innovation during the Covid-19 pandemic as well as direct involvement of the PU in the East Coast zone of Malaysia namely Kelantan, Terengganu, and Pahang. Seven PU were selected namely UniSZA and UMT in Terengganu, UiTM, USM and UMK in Kelantan as well as UMP and UIAM in Pahang. The selection was made based on direct involvement in the development of innovative products based on the internet search. It also recognizes the capabilities, expertise, and facilities available especially in the areas of design, technology, and manufacturing. The information presented in this paper is fully obtained through literature studies, direct observations, and findings from previous research. Several examples of innovative products such as sanitation tunnels, personal protective equipment, cubical and disinfectant fluids developed by the seven PU's are presented and clearly described in their manufacturing, technology and uses. This paper concludes that the contribution of the innovative products provided by the PU had a huge impact on the country. This noble effort is a testimony of the love among Malaysians that is very strong in the face of misfortune, and it must be continued for the well-being of the people and the prosperity of the country.